XL413 hydrochloride

CAS No. 1169562-71-3

XL413 hydrochloride( —— )

Catalog No. M17164 CAS No. 1169562-71-3

XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 110 Get Quote
10MG 152 Get Quote
25MG 266 Get Quote
50MG 447 Get Quote
100MG 651 Get Quote
500MG 1368 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    XL413 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.
  • Description
    XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.(In Vitro):XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC50=2685 nM), decreases cell viability (IC50=2142 nM) and elicits the caspase 3/7 activity (EC50=2288 nM) in Colo-205 cells. XL413 hydrochloride also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC50=715 nM).XL413 hydrochloride shows cytotoxic effects on tumors, with IC50 of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. XL413 hydrochloride induces apoptosis in the Colo-205 cells, but not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC50 of 22.7 nM. XL413 hydrochloride is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.(In Vivo):XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    CK2| Cdc7| Pim1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1169562-71-3
  • Formula Weight
    326.18
  • Molecular Formula
    C14H13Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 3.4 mg/mL
  • SMILES
    c1([nH]c2c(c(=O)n1)oc1c2cc(cc1)Cl)[C@H]1NCCC1.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Koltun ES, et al. Bioorg Med Chem Lett. 2012, 22(11), 3727-3731.
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